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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
14.85
Human Site:
Y272
Identified Species:
25.13
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
Y272
E
D
M
E
A
S
D
Y
E
L
E
D
E
T
R
Chimpanzee
Pan troglodytes
XP_521839
646
71607
Y272
E
D
M
E
A
S
D
Y
E
L
E
D
E
T
R
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
V227
G
V
G
E
F
G
T
V
Y
K
C
I
K
R
L
Dog
Lupus familis
XP_534051
887
95991
Y513
E
D
M
E
A
S
D
Y
E
L
E
D
E
T
R
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
Y271
E
D
M
E
A
S
D
Y
E
F
E
D
E
T
R
Rat
Rattus norvegicus
Q63802
646
71478
E272
D
M
E
A
S
D
Y
E
F
E
D
E
T
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
I231
E
F
H
E
L
E
K
I
G
S
G
E
F
G
S
Chicken
Gallus gallus
NP_001026352
641
70947
E268
D
M
E
A
S
D
G
E
P
E
D
E
T
I
R
Frog
Xenopus laevis
P47817
555
61670
I213
Y
K
T
E
F
L
E
I
E
K
I
G
A
G
E
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
S259
M
M
E
N
N
M
M
S
R
Y
A
S
E
F
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
L260
V
F
Q
C
V
N
R
L
D
G
C
I
Y
A
I
Honey Bee
Apis mellifera
XP_624069
589
66032
Y248
T
G
E
F
G
S
V
Y
K
C
I
N
R
L
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
A267
E
N
P
A
K
R
I
A
L
R
D
S
D
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
R159
S
T
W
S
S
K
H
R
V
D
E
Q
E
N
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
6.6
100
N.A.
93.3
0
N.A.
13.3
6.6
13.3
6.6
N.A.
0
13.3
N.A.
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
26.6
N.A.
20
33.3
20
6.6
N.A.
13.3
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
29
0
0
8
0
0
8
0
8
8
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
8
15
0
0
0
0
% C
% Asp:
15
29
0
0
0
15
29
0
8
8
22
29
8
0
15
% D
% Glu:
43
0
29
50
0
8
8
15
36
15
36
22
43
0
8
% E
% Phe:
0
15
0
8
15
0
0
0
8
8
0
0
8
8
0
% F
% Gly:
8
8
8
0
8
8
8
0
8
8
8
8
0
15
0
% G
% His:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
8
15
0
0
15
15
0
15
8
% I
% Lys:
0
8
0
0
8
8
8
0
8
15
0
0
8
0
0
% K
% Leu:
0
0
0
0
8
8
0
8
8
22
0
0
0
8
8
% L
% Met:
8
22
29
0
0
8
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
8
8
8
0
0
0
0
0
8
0
8
0
% N
% Pro:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
8
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
8
8
8
8
8
0
0
8
15
36
% R
% Ser:
8
0
0
8
22
36
0
8
0
8
0
15
0
0
15
% S
% Thr:
8
8
8
0
0
0
8
0
0
0
0
0
15
29
0
% T
% Val:
8
8
0
0
8
0
8
8
8
0
0
0
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
8
36
8
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _